23andMe’s bankruptcy serves as a moment of reflection for the direct-to-consumer (DTC) genomics industry. We analyzed 23andMe financial data and business practices to reveal the factors behind the fall of the company, once valued at US $6 billion and now being considered for acquisition by Regeneron for merely $250 million. Key challenges faced by 23andMe in monetizing its genomic data reveal that this information, at least in a typical DTC setting, is simply not worth that much.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout

Change history
03 June 2025
In the version of this article initially published, the correct affiliation for Dina Zielinski (Geneticancer, Paris, France) was not listed, while in Table 1, the status for Knome (Acquired by Tute Genomics) was incorrect. The affiliation and table are now corrected in all versions of the article.
References
Lee, S. S.-J. & Crawley, L. Am. J. Bioeth. 9, 35–44 (2009).
Davies, K. The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine (Simon and Schuster, 2015).
Larkin, L. DNA tests. The DNA Geek https://thednageek.com/dna-tests/ (2023).
Nat. Biotechnol. https://doi.org/10.1038/nbt.2805 (2014).
Natarajan, P. et al. Circulation 135, 2091–2101 (2017).
Brown, S. N., Jouni, H., Marroush, T. S. & Kullo, I. J. Circ. Cardiovasc. Genet. 10, e001613 (2017).
Polygenic Risk Score Task Force of the International Common Disease Alliance. et al. Nat. Med. 27, 1876–1884 (2021).
Minikel, E. V., Painter, J. L., Dong, C. C. & Nelson, M. R. Nature 629, 624–629 (2024).
Phares, S., Phillip, K. & Trusheim, M. Nat. Rev. Drug Discov. https://doi.org/10.1038/d41573-025-00036-8 (2025).
Sudlow, C. et al. PLoS Med. 12, e1001779 (2015).
Sheridan, C. Nat. Biotechnol. 31, 87–88 (2013).
Benjamin, J. S. et al. Cancer Res. Commun. 5, 477–496 (2025).
Fenaux, J. et al. Oncoimmunology 12, 2217737 (2023).
Dorfman, R. Nat. Biotechnol. 31, 785–786 (2013).
Wojcicki, A. Nat. Biotechnol. 31, 1075–1076 (2013).
Khan, R. & Mittelman, D. Genome Biol. 14, 139 (2013).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
Y.E. is an employee and shareholder of Eleven Therapeutics, an RNA Therapeutic start-up. D.Z. is an employee and shareholder of WhiteLab Genomics, a gene and cell therapy company.
Supplementary information
Supplementary Information (download PDF )
Supplemental Figure 1-3, Supplemental Note 1-3
Supplementary Table (download XLSX )
Quarterly analysis of public financial information
Rights and permissions
About this article
Cite this article
Erlich, Y., Zielinski, D. Anatomy of the 23andMe fall and implications for consumer genomics. Nat Biotechnol 43, 854–856 (2025). https://doi.org/10.1038/s41587-025-02683-z
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41587-025-02683-z