Extended Data Fig. 4: Gene Ontology analysis.
From: Genome-wide mapping of RNA-protein associations through sequencing
(a, d, f) The number of genes (x axis) in each GO term (dot) is plotted against the significance level (y axis) of this term in the HuRPA proteins. To avoid very general GO terms, we restricted our analysis to Biological Process (BP) terms with no more than 1,000 genes per term (a), and Cellular Component (CC) and Molecular Function (MF) terms with no more than 100 genes per term (d, f). Additionally, we annotated the most notable BP, CC, and MF terms with no more than 1,100, 110, and 110 genes, respectively (a, d, f). (b, e, g) The numbers of RNA-protein associations (RPAs), RNAs, and proteins in the HuRPA subnetworks associated with the most notable GO terms: ‘RNA processing’ (b), ‘cytoplasmic stress granule’ (e), and ‘translation factor activity, RNA binding’ (g). (c) Distribution of ‘RNA processing’ associated HuRPA proteins across different protein classes.
