Extended Data Fig. 5: Codon and amino acid changes enabled by AIM-A, AIM-C, and AIM-A&C.
From: Single-strand deaminase-assisted editing for functional RNA manipulation
a, Circos plots showing the specific codon changes enabled by AIM-A (left), AIM-C (middle), and AIM-A&C (right), respectively. AIM-A induces 61 different types of codon changes, 46 of which (orange, 75.4%) result in amino acid substitutions. AIM-C can induce 61 different types of codon change, with 43 (green, 70.5%) leading to amino acid changes. AIM-A&C can induce 30 different types of codon alterations, 29 of which (red, 97%) change amino acids. b, Tables summarizing the codon and amino acid changes enabled by AIM-A (left), AIM-C (middle), and AIM-A&C (right). Codon changes leading to different amino acids, induced by the AIM-A or AIM-C tools, are underlined in black. Codons uniquely altered by AIM-A&C are highlighted in green.
