Extended Data Fig. 8: Summary of ABE7.10 mutated residues reversion impact on editing activity.
From: Precise, minimally evolved adenine base editors generated through mutation reversion analysis
Modeled structure of TadA*7.10 (prepared as described in Fig. 1), highlighting how individual reversion mutations impacted ABE editing activity. Scale shows most inhibitory reversions to ABE editing activity (red) through residues where reversions had minimal impact on editing activity (grey), and residues where reversions enhanced editing activity (green). The Y147D reversion is highlighted in magenta, as its activity was strongly host-dependent.
