The National Cancer Institute (NCI) Genomic Data Commons (GDC) contains more than 2.9 petabytes of genomic and associated clinical data from more than 60 NCI-funded and other contributed cancer genomics research projects. The GDC consists of five applications over a common data model and a common application programming interface.
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Change history
18 May 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00883-2
References
Grossman, R. L. Cancer J. 24, 122–126 (2018).
Grossman, R. L., Heath, A., Murphy, M., Patterson, M. & Wells, W. Comput. Sci. Eng. 18, 10–20 (2016).
Wilkinson, M. D. et al. Sci. Data 3, 160018 (2016).
Lawrence, M. S. et al. Nature 505, 495–501 (2014).
Wilson, S. et al. Cancer Res. 77, e15–e18 (2017).
Leek, J. T. et al. Nat. Rev. Genet. 11, 733–739 (2010).
Mailman, M. D. et al. Nat. Genet. 39, 1181–1186 (2007).
Heath, A. P. et al. J. Am. Med. Inform. Assoc. 21, 969–975 (2014).
Hinkson, I. V. et al. Front. Cell Dev. Biol. 5, 83 (2017).
Zhang, Z. et al. Nat. Commun. https://doi.org/10.1038/s41467-021-21254-9 (2021).
Jia, P. et al. Genome Biol. 15, 489 (2014).
Lillie, E. O. et al. Per. Med. 8, 161–173 (2011).
Levine, R. L. et al. Cancer Cell 7, 387–397 (2005).
Acknowledgements
This project was funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, agreement 14X050 and task order T02 under agreement 17X147 under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. The project is grateful for the contributions of S. Marechek and E. Miller, both of whom have passed away.
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The GDC software was developed and tested by A. Khurana, A. Kadam, A.W., A.H., A.C., A.Z., B.F.C., B.L.W., B.R., B.B., C.F.B., C.W., C.D., C.K.Y., C.Y., C.P.R., F. Gomez, F. Gerthoffert, F.C., G.L.G., I.M., J.C.A., J.J.P., J.B., J.A.M., J.P., J. Spring, J. Sislow, J.T.Y., J.S.M., J.Z., J.H.B.B., K.W., K.H., K.R., K.C., K.M., K.M.J.K., K.A.S., L.L., L.X., M.A., M.W.M., M.Y.P., M.S.F., M. Ford, M. Fukuma, P.L.P., P.-M.D., P.M., R.P., R.A., R.L.G., R.B., R.J., R.O.O., S.R., S.S., S.W., S.J., S.A., T.N., T.I.G., V.E.K., V.F., W.P.W., Y.T. and Y.Z. Bioinformatics, data curation and data modeling were performed by A.P.K., D.P.M., F.M.O., J.H.S., J.Z., K.M.H., L.S., M.A.J., M.L.F., R.L.G., R.B., S.L., T.M.L., T.I.G., V.F., W.P.W., Z.Z. and Z.W. The project managers were A.P.H., B.I., C.K.Y., D.S.G., E.M., F.G., H.D.T., H.S., J.L., J.C.Z., L.Y., L. Stein, L. Staudt, M.A.J., M.L.F., M.T., R.L.G., S.S.G., S.G., T.D., T.J.S., V.F. and Z.W. The manuscript was written and revised by A.P.H., D.S.G., J.C.Z., L. Staudt, R.L.G. and Z.Z.
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Heath, A.P., Ferretti, V., Agrawal, S. et al. The NCI Genomic Data Commons. Nat Genet 53, 257–262 (2021). https://doi.org/10.1038/s41588-021-00791-5
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