The human endometrium exhibits complex signaling cascades mediated by spatial–temporal cellular interactions. Understanding the normal endometrial microenvironment is the first step towards understanding diseases of endometrial dysfunction.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
A spatial transcriptomics dataset of the endometrium from repeated implantation failure patients
Scientific Data Open Access 29 October 2025
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 /Â 30Â days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout

References
Greaves, E., Critchley, H. O. D., Horne, A. W. & Saunders, P. T. K. Acta Obstet. Gynecol. Scand. 96, 644–658 (2017).
Maurya, V. K., DeMayo, F. J. & Lydon, J. P. Front. Cell. Dev. Biol. 9, 640907 (2021).
Garcia-Alonso, L. Nat. Genet. https://doi.org/10.1038/s41588-021-00972-2 (2021).
Wang, W. et al. Nat. Med. 26, 1644–1653 (2020).
Kelleher, A. M., DeMayo, F. J. & Spencer, T. E. Endocr. Rev. 40, 1424–1445 (2019).
Tempest, N., Maclean, A. & Hapangama, D. K. Int. J. Mol. Sci. 19, 3240 (2018).
Burney, R. O. et al. Endocrinology 148, 3814–3826 (2007).
Bulun, S. E. et al. Endocr. Rev. 40, 1048–1079 (2019).
Flores, V. A., Vanhie, A., Dang, T. & Taylor, H. S. J. Clin. Endocrinol. Metab. 103, 4561–4568 (2018).
Zhou, W., Menkhorst, E. & Dimitriadis, E. FASEB J. 35, e21784 (2021).
Boretto, M. et al. Development 144, 1775–1786 (2017).
Vallve-Juanico, J., Houshdaran, S. & Giudice, L. C. Hum. Reprod. Update 25, 564–591 (2019).
Boretto, M. et al. Nat. Cell Biol. 21, 1041–1051 (2019).
Turco, M. Y. et al. Nat. Cell Biol. 19, 568–577 (2017).
Rawlings, T. M. et al. eLife 10, e69603 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wang, X., Hawkins, S.M. Using advanced spatial and single-cell transcriptomics to characterize the human endometrium. Nat Genet 53, 1628–1630 (2021). https://doi.org/10.1038/s41588-021-00982-0
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41588-021-00982-0