Fig. 5: Multitrait colocalization of cis-eQTLs and cis-sQTLs with molecular phenotypes and health outcomes. | Nature Genetics

Fig. 5: Multitrait colocalization of cis-eQTLs and cis-sQTLs with molecular phenotypes and health outcomes.

From: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes

Fig. 5

a, Putative pathways and directions of the effect of sQTL signals for IL7R and WARS1 associated with plasma protein quantity, dermatitis and eczema, and hypertension, respectively. The image depicting ‘soluble protein’ was reproduced from a public database (PDB code 2F6W). b, Gene-level summary of colocalization of cis-eQTL and cis-sQTL with COVID-19 HGI summary statistics. The red dashed line represents genome-wide significance (P = 5 × 10−8) and the height toward the center represents the significance of the GWAS association. c, Example of a multitrait colocalization for COVID-19 in OAS1, with GWAS summary statistics, cis-pQTL, cis-eQTL and cis-sQTL.

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