Fig. 6: UV-related signatures in HNC.
From: The complexity of tobacco smoke-induced mutagenesis in head and neck cancer
a, Mutational burdens for mutational signatures related to UV light exposure showing positive associations with the HNC anatomical subsite (n = 265 biologically independent samples). The Kruskal–Wallis test (two-sided) was used to test for global differences. Box-and-whisker plots are in the style of Tukey. The line within the box is plotted at the median, while the upper and lower ends indicate the 25th and 75th percentiles. Whiskers show 1.5× IQR. Frequencies of positive samples in each category are indicated in bar plots. b, SBS, DBS and indel signature burdens in samples positive for UV exposure based on relative SBS7a–c contributions above 10% of relative mutational burdens. Samples are sorted by lip (inner, n = 3 or unspecified, n = 1), tongue and floor of the mouth location within the OC. Positive tobacco and alcohol status are indicated in black.
