Fig. 5: Genetic associations with transcriptional states and GBM multilayered ecosystems.

a, Association between genetic aberrations and malignant cell-state abundance. Two-sided Wilcoxon rank-sum tests are presented. P value adjustments for multiple hypothesis testing were not performed. b, Cell type composition of each of the tumors (n = 121) in the dataset, aggregated based on their composition group. c, Malignant cell-state proportions (rows) in each tumor sample (n = 111 with at least 50 malignant cells; columns). Tumors are aggregated according to the dominant malignant state (at least 30% of cells). d, Interaction graph between the different layers of GBM (composition groups, malignant state groups, BPs, gene-level CNAs and single-nucleotide mutations). Each node represents a layer; nodes are connected with an edge if a statistically significant association exists between the nodes. mut, mutation.