Extended Data Fig. 5: Spatial distribution of cell types across all tissue sections. | Nature Genetics

Extended Data Fig. 5: Spatial distribution of cell types across all tissue sections.

From: Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network

Extended Data Fig. 5: Spatial distribution of cell types across all tissue sections.The alternative text for this image may have been generated using AI.

For non-stricturing (top) and stricturing (bottom) tissue sections (columns), the spatial distributions of spot clusters, radial axis scores and the cell lineage proportions for B cells, epithelial cells, fibroblasts, myeloid cells, pericytes and T cells across all profiled spots. Cell-type proportions in each spot were estimated from the deconvolution with BayesPrism. Muscle cells were absent from the single-cell atlas and not included in the deconvolution, which substituted them with the most transcriptionally similar cell types, pericytes and myofibroblasts. Radial axis scores were congruent with the proportions of epithelial cells and pericytes (muscle). Scale bars, 2 × 2.5 mm (all images).

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