Fig. 2: Association of PGSALZ with Aβ42 and p-tau in cerebrospinal fluid. | Nature Genetics

Fig. 2: Association of PGSALZ with Aβ42 and p-tau in cerebrospinal fluid.

From: Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Fig. 2: Association of PGSALZ with Aβ42 and p-tau in cerebrospinal fluid.The alternative text for this image may have been generated using AI.

a–c, Association of PGSALZ with the level of normalized Aβ42 (a) and p-tau (b) in cerebrospinal fluid (n = 13,004) across European ancestry populations and according to PGSALZ strata (0–20%, 20–40%, 60–80% and 80–100%) (c); the 40–60% PGSALZ stratum was used as the reference. β values were calculated by general linear model and logistic regression adjusted for APOE, age, gender, ten first PCs and chip center if necessary. The horizontal lines in the forest plots indicate the 95% CI of each β value. If heterogeneity P (HetP) < 0.05, a random effect is shown for the meta-analysis results. I2; heterogeneity.

Back to article page