Fig. 3: Association of PGS^ALZ across multiancestry populations.

a, Association of PGS^ALZ with the risk of developing AD in multiancestry populations. The European ancestry meta-analysis includes MVP and Australia. The African American ancestry (more than 75% AA ancestry) meta-analysis includes MVP and ADSP. The East Asia meta-analysis includes China, Korea and Japan. The Latin American ancestry (self-reported) meta-analysis includes MVP and ADSP. The South America meta-analysis includes Argentina, Brazil, Chile and Colombia. b, The risk of developing AD, according to PGS^ALZ (logistic regression adjusted or not for APOE or included APOE variants) strata (0–20%, 20–40%, 60–80% and 80–100%) in multiancestry populations. The 40–60% PGS^ALZ stratum was used as the reference in each population, and results were meta-analyzed. The European ancestry meta-analysis includes MVP and Australia. The African American ancestry meta-analysis includes MVP and ADSP. The East Asia meta-analysis includes China, Korea and Japan. The Latin American ancestry meta-analysis includes MVP and ADSP. The South America meta-analysis includes Argentina, Brazil, Chile and Colombia. N_cases, number of cases; N_controls, number of controls. OR per s.d. was calculated by logistic regression adjusted for APOE, age, sex and specific PCs according to the study (Supplementary Table 2). The lines in the Forest plots indicate the 95% CI of each OR. If HetP < 0.05, a random effect is shown for the meta-analysis results. AA, African American; EUR, European; LA, Latin American.