Fig. 4: Comparison of the association of PGSALZ or PRS (excluding the APOE region) with the AD risk and the corresponding predictive values (adjusted Nagelkerke R2 and liability R2). | Nature Genetics

Fig. 4: Comparison of the association of PGSALZ or PRS (excluding the APOE region) with the AD risk and the corresponding predictive values (adjusted Nagelkerke R2 and liability R2).

From: Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Fig. 4: Comparison of the association of PGSALZ or PRS (excluding the APOE region) with the AD risk and the corresponding predictive values (adjusted Nagelkerke R2 and liability R2).The alternative text for this image may have been generated using AI.

All PGSALZ and PRS values were adjusted for interpopulation differences in distribution; PRSEUR were generated by using only European ancestry summary statistics; PRSCOMB were generated by combining European, African American, Latin American and East Asian ancestry summary statistics. The sparseness parameter was set to 10−8, 10−7, 10−6, 10−5, 10−4, 10−2 or 1. OR per s.d. was calculated by logistic regression adjusted for age, sex and specific PCs according to the study (Supplementary Table 2). MVP EUR (4,561 AD cases and 84,587 controls), MVP LA (375 AD cases and 7,166 controls), MVP AA (713 AD cases and 19,405 controls) and South Korea (1,119 AD cases and 1,172 controls).

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