Extended Data Fig. 5: Low proportion of asRS sharing across cell lines can be attributed to their unique genetic backgrounds.
From: Genetic variants affecting RNA stability influence complex traits and disease risk
a, UpSet plot of asRS genes that are unique to or shared across cell lines. b,c UpSet plot of heterozygous single-nucleotide variants (SNVs) within genes classified by RNAtracker (b), as well as all (including intronic) heterozygous SNVs (c) that are unique to or shared across cell lines. Note that Calu3 is not shown because only the top 30 largest intersections are plotted. d, UpSet plot of all genes categorized by RNAtracker across cell lines. e, UpSet plot of asRS variants that are unique to or shared across cell lines. f, Pairs of cell lines that exhibited a significant difference between the expected and actual proportion of overlapping asRS variants. All 24 comparisons had significantly greater actual proportion than expected. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 (two-sided binomial test).
