Extended Data Fig. 8: asRS variants may function by disrupting interactions with trans-regulatory factors.
From: Genetic variants affecting RNA stability influence complex traits and disease risk
a, RNA binding proteins (RBPs) with allele-specific binding (ASB) sites that overlap asRS variants. X axis shows percentage of each RBP’s ASB sites that overlap asRS variants. Number of ASB sites that overlap asRS variants is shown to the right of each bar. Purple: RBPs involved with RNA stability and decay according to previous manual literature curation. b, Proportion of miRNA target gain/loss SNPs that overlap asRS or control variants in each cell line (n = 11). In boxplots, minima/maxima represent least/greatest proportion values, bounds show 25th and 75th percentiles, and whiskers indicate values within 1.5 * the interquartile range.
