Fig. 7: Enrichment between cell types and complex traits.
a, Correlations between cell lineages and complex traits. The heatmap represents the significant level of each cell lineage with traits. Top, The gray squares represent trait groups. b,c, Correlations between milk production (b) and male fertility (c) traits and cell types. Each circle represents a cell type–trait association. The x axis represents cell lineages sorted alphabetically. d–f, Correlation between cell types and traits in tissues. d, Cerebral cortex. e, Esophagus. f, Testis. The violin plot presents the TRS for each cell type with the corresponding trait. The red line represents the significance level (−log10(P)) for each cell type with the corresponding trait under a two-sided hypergeometric test. g, Active KEGG pathways in the top significant trait-relevant cell types. Dot size represents the significance level (−log10(P)) of pathway activity; the dot color represents the significance level (FDR) after multiple comparisons of the enrichment between active pathway genes and top trait-relevant genes in the given cell type.
