Extended Data Fig. 10: Impacts of OTX2/TPRXL dKD for gene expression on day 4.
From: Maternal factor OTX2 regulates human embryonic genome activation and early development
(a) Heatmaps showing the average mRNA levels of 4C to ICM stage-specifically activated genes in normal embryos across stages22, as well as in the control and OTX2 single KD/dKD embryos on D4. Genes down-regulated (computed by DESeq2) and unaffected are labeled by the red and blue bars, respectively. (b) Venn diagram showing the overlapped genes that are down-regulated on day 3 and day 4 in dKD embryos. P-value (Fisher’s test) is shown. (c) Venn diagram showing the overlapped genes that are down-regulated in OTX2 single KD and dKD embryos on day 4. P-value (Fisher’s test) is shown.
