Extended Data Fig. 3: Unique spatial niches identified in CosMx SMI and CODEX. | Nature Genetics

Extended Data Fig. 3: Unique spatial niches identified in CosMx SMI and CODEX.

From: Multi-modal spatial characterization of tumor immune microenvironments identifies targetable inflammatory niches in diffuse large B cell lymphoma

Extended Data Fig. 3: Unique spatial niches identified in CosMx SMI and CODEX.

a, Ro/e plot showing the enrichment or depletion of different cell states in each spatial niche. C5_T, C1_PC_IgG, C6_TAM_APOE_C1Q and C11_FRC were highly enriched in CN1 ~ 4, respectively. C0_Tumor-B were highly enriched in CN5 and CN6. No obvious enrichment of any single cell state was observed in CN7. b, Pie chart representation of the proportion of cells in the CosMx SMI dataset that resided in each spatial niche. c, Additional examples of cellular niches, corresponding to Fig. 2g. d, Representative CODEX images of tissue sections from the first five samples shown in Fig. 2g, with spatial enrichment of T cells, PCs, myeloid cells, stromal cells, and B cells, respectively.

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