Fig. 2: Putative sex-differential loci and reclassification of established lipid loci.
From: A genetic map of human metabolism across the allele frequency spectrum
a, Comparison of effect sizes of putatively sex-differential loci (defined as loci with heterogeneity P < 5 × 10−8 in a two-sided Z-score meta-analysis across the sexes). b, Rank distributions for each of the five matching NMR traits compared with the Lipids Genetics traits across genetic loci. Per locus–trait combination, 205 lipid-related NMR traits were ranked based on their absolute effect size and compared with the NMR trait that corresponds the Lipids Genetics consortium trait. Pie charts show the percentage of loci where the corresponding NMR trait is ranked among the top 10% of associated traits. TC, total cholesterol; TG, triglycerides.
