Fig. 1: Association of CD36 locus with DCM and validation of rs3211938 in left ventricular phenotypes among AFR individuals. | Nature Genetics

Fig. 1: Association of CD36 locus with DCM and validation of rs3211938 in left ventricular phenotypes among AFR individuals.

From: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy

Fig. 1: Association of CD36 locus with DCM and validation of rs3211938 in left ventricular phenotypes among AFR individuals.

a, Manhattan plot showing the association between common genetic variants and DCM across the genome in AFR individuals. b, Regional association plot of the CD36 locus, displaying variant-level associations and linkage disequilibrium with the lead SNP (rs3211916) based on the 1000 Genomes AFR population. c, Association of heterozygous (T/G) and homozygous (G/G) rs3211938 genotypes with DCM (versus the reference genotype (T/T)) in African ancestry participants of the VA MVP and PMBB, estimated using logistic regression adjusted for age, sex and the first ten principal components. Data are shown as ORs with 95% CIs. d, Associations of rs3211938 genotypes with cardiac MRI-derived left ventricular traits in African ancestry participants from the UKB, MESA and JHS. Associations were estimated using linear regression adjusted for age, sex and the first ten principal components. Data are presented as the mean difference relative to T/T homozygotes (per s.d. increase in trait) with 95% CIs. Only the meta-analysis results are shown; full results are provided in Supplementary Fig. 6. LVESVi, left ventricular end-systolic volume indexed for body surface area; LVEDVi, left ventricular end-diastolic volume indexed for body surface area; LVMi, left ventricular mass indexed for body surface area.

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