Fig. 2: Associations of rs3211938 with binary outcomes and continuous traits from a phenome-wide association analysis. | Nature Genetics

Fig. 2: Associations of rs3211938 with binary outcomes and continuous traits from a phenome-wide association analysis.

From: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy

Fig. 2: Associations of rs3211938 with binary outcomes and continuous traits from a phenome-wide association analysis.

a, Phenome-wide association results for binary traits (PheCodes) tested in up to 121,078 AFR ancestry participants of the VA MVP using logistic regression and adjusted for age, sex and ten principal components. Of 1,805 PheCodes tested, only those reaching Bonferroni-corrected significance threshold (P < 2.77 × 10−5) are shown. Results are presented as ORs with 95% CIs. b, Association of rs3211938 with continuous traits in AFR participants from MVP and UKB, tested using linear regression adjusted for age, sex and ten principal components. Traits were scaled to have a mean of zero and s.d. of 1. Of 247 traits tested, only those reaching Bonferroni-corrected significance (P < 2.02 × 10−4) are shown. Results are presented as MD per additional risk (G) allele (per s.d. increase in trait) with 95% CIs. †Estimates calculated in the UK Biobank population; all others from MVP. All analyses used an additive genetic model with the G allele at rs3211938 as the effect allele. MD, mean difference.

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