We found that two key transcription factors contribute to disease progression in the classical subtype of pancreatic ductal adenocarcinoma. In the primary tumor context, the nuclear receptor HNF4G is the critical driver, but during the transition to metastasis, FOXA1 is derepressed and mediates metastatic potential.
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References
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This is a summary of: Rao, S. V. et al. Transcription factor switching drives subtype-specific pancreatic cancer. Nat. Genet. https://doi.org/10.1038/s41588-025-02389-7 (2025).
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Defining the transcriptional landscape in the classical subtype of pancreatic cancer. Nat Genet 57, 2950–2951 (2025). https://doi.org/10.1038/s41588-025-02392-y
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DOI: https://doi.org/10.1038/s41588-025-02392-y
