Molecular biology articles from across Nature Portfolio

EGFR amplification is common in glioblastoma and represents a therapeutic challenge, conferring resistance to targeted treatment. A new study reveals that the same locus hides the HELDR lncRNA, which epigenetically activates KAT7 to drive growth independently of EGFR. Targeting HELDR or KAT7 may improve anti-EGFR therapies in glioblastoma.

Subcellular mRNA localization relies on the recognition of cis-regulatory elements by trans-acting complexes, which mediate mRNA recruitment to the transport machineries. A study now defines the previously unclear rules that govern mRNA recognition by the Egalitarian–BicaudalD complex, a trigger for dynein-dependent transport.

The alarming rise in the incidence of colorectal cancer among younger individuals is probably due to environmental factors; epigenetic signatures of exposures may help uncover drivers of this trend, but questions remain.

The CAG tract length influences Huntington’s disease onset but alone may not be sufficient to drive neuronal death. Here, the authors report that double strand breaks induce neuronal death, regardless of somatic expansion of the inherited disease allele.

EGFR amplification is common in glioblastoma and represents a therapeutic challenge, conferring resistance to targeted treatment. A new study reveals that the same locus hides the HELDR lncRNA, which epigenetically activates KAT7 to drive growth independently of EGFR. Targeting HELDR or KAT7 may improve anti-EGFR therapies in glioblastoma.

Subcellular mRNA localization relies on the recognition of cis-regulatory elements by trans-acting complexes, which mediate mRNA recruitment to the transport machineries. A study now defines the previously unclear rules that govern mRNA recognition by the Egalitarian–BicaudalD complex, a trigger for dynein-dependent transport.

The Single Cell Notebooks provide multilingual, open-access training materials for single-cell and spatial transcriptomics analysis through reusable notebooks. They have evolved into a community-driven platform for education and capacity building, lowering language and computational barriers to support equitable participation in omics research.

The alarming rise in the incidence of colorectal cancer among younger individuals is probably due to environmental factors; epigenetic signatures of exposures may help uncover drivers of this trend, but questions remain.

Tandem duplications are frequent forms of genomic rearrangements with important implications in cancer biology and plant adaptation. Two new studies identify TONSL as a conserved suppressor of large tandem duplications by preventing the repair of broken replication forks through mutagenic mechanisms.