Extended Data Fig. 4: Enriched biological processes in polycystic ovary syndrome associated genes.
From: Multi-ancestry genome-wide association analyses of polycystic ovary syndrome
a, Biological process enrichment in the associated gene sets. Heatmap showing enrichment of biological processes across polycystic ovary syndrome (PCOS) associated gene sets from East Asian (EAS) and European (EUR) populations, where color intensity represents -log₁₀(P-value), with darker orange indicating stronger enrichment (see color key within figure). Each row represents a biological process term, and columns represent different gene sets. b, Hierarchical clustering of enriched functional terms. Hierarchical organization of enriched terms according to Gene Ontology (GO) parent-child relationships, with color coding following panel (a). Enrichment analysis employed a one-sided hypergeometric test to identify over-represented biological processes. Multiple testing correction was applied using the Benjamini-Hochberg method with FDR < 0.05 as the significance threshold. Heatmap colors represent −log₁₀(adjusted P-values).
