Table 2 Disease-relevant pQTLs from deCODE and UKB-PPP with >99% power that were replicated and had an MSPA score >0.8
Assay (platform) | Protein description | GWAS trait | P value | PMID |
|---|---|---|---|---|
ACP1 (S,O) | Acid phosphatase 1 | Estimated glomerular filtration rate | 1 × 10−11 | 31152163 |
ASPN (S) | Asporin | Systolic blood pressure | 9 × 10−13 | 30224653 |
CD109 (O) | CD109 molecule | Heel bone mineral density | 8 × 10−10 | 30598549 |
CFB (O) | Complement factor B | Age-related macular degeneration | 6 × 10−31 | 21665990 |
COLEC11 (S) | Collectin subfamily member 11 | Liver enzyme levels | 1 × 10−34 | 33972514 |
CTSB (S,O) | Cathepsin B | Parkinson’s disease | 4 × 10−16 | 31701892 |
CYTL1 (S) | Cytokine like 1 | Peak expiratory flow | 4.2 × 10−37 | 30804560 |
F11 (S,O) | Coagulation factor XI | Venous thromboembolism | 8 × 10−96 | 31676865 |
FGL1 (S,O) | Fibrinogen-like 1 | Lung function (FEV1/FVC) | 6 × 10−21 | 30595370 |
IL7R (O) | Interleukin 7 receptor | Hay fever and/or eczema | 1 × 10−48 | 31361310 |
LPA (O) | Lipoprotein(a) | Coronary artery disease | 3 × 10−103 | 33020668 |
LTBP3 (O) | Latent transforming growth factor β-binding protein 3 | Lung function (FEV1/FVC) | 6 × 10−13 | 30595370 |
MBL2 (S,O) | Mannose-binding lectin 2 | Heel bone mineral density | 4.7 × 10−13 | 30598549 |
MFAP2 (S) | Microfibril-associated protein 2 | Lung function (FEV1/FVC) | 7 × 10−76 | 30595370 |
NID2 (S,O) | Nidogen 2 | Colon polyp | 6 × 10−11 | 34594039 |
PLTP (S,O) | Phospholipid transfer protein | HDL-cholesterol levels | 6 × 10−263 | 34226706 |
SFTPD (O) | Surfactant protein D | Lung function (FEV1/FVC) | 2.1 × 10−19 | 34226706 |
SHBG (O) | Sex hormone-binding globulin | Type 2 diabetes (adjusted for BMI) | 1 × 10−10 | 30297969 |
TGFBI (S,O) | Transforming growth factor β induced | Insomnia | 4 × 10−17 | 30804565 |
VMO1 (O) | Vitelline membrane outer layer 1 homolog | LDL-cholesterol levels | 1.6 × 10−11 | 32493714 |
