Table 3 Disease-relevant pQTLs from deCODE and UKB-PPP with >99% power that were not replicated and had an MSPA score <0.2

APOA5 (S)

Apolipoprotein A5

Cardiovascular disease

7.1 × 10⁻¹⁴

33959723

x

.

APOBR (O)

Apolipoprotein B receptor

Crohn’s disease

6.9 × 10⁻²²

26192919

x

2

APOL1 (O)

Apolipoprotein L1

Glomerulosclerosis

5 × 10⁻¹³

20668430

x

2

F13B (O)

Coagulation factor XIII B chain

Systolic blood pressure

3 × 10⁻⁹

33230300

.

.

FCGR2A (S)

Fcγ receptor IIa

Ulcerative colitis

1.4 × 10⁻⁴¹

26192919

.

.

FCGR2A (O)

Fcγ receptor IIa

Aspartate aminotransferase levels

4 × 10⁻³⁴

33462484

x

1

GDF15 (S)

Growth differentiation factor 15

Severity of nausea and vomiting of pregnancy

2 × 10⁻⁴¹

29563502

x

1

ICAM1 (O)

Intercellular adhesion molecule 1

Liver enzyme levels

3 × 10⁻¹¹

33972514

x

.

IGFBP3 (O)

Insulin-like growth factor-binding protein 3

Pulse pressure

6.7 × 10⁻¹⁰⁸

33230300

x

2

ITGB6 (O)

Integrin subunit β₆

Adolescent idiopathic scoliosis

2 × 10⁻³¹

30019117

.

.

ITIH3 (S)

Inter-α-trypsin inhibitor heavy chain 3

Bipolar disorder

5 × 10⁻¹⁴

33479212

x

1

ITIH3 (O)

Inter-α-trypsin inhibitor heavy chain 3

Osteoarthritis (with total hip replacement)

1 × 10⁻¹⁶

34450027

.

.

LPL (O)

Lipoprotein lipase

Coronary artery disease

3.9 × 10⁻¹¹

29212778

x

.

MFGE8 (O)

Milk fat globule EGF and factor V or VIII domain containing

Liver enzyme levels

7 × 10⁻²⁰

33972514

.

.

SERPING1 (S)

Serpin family G member 1

Lung function (FEV₁/FVC)

1.8 × 10⁻¹⁰

30804560

x

2

TGOLN2 (O)

Trans-Golgi network protein 2

HDL-cholesterol levels

1 × 10⁻¹²

32203549

x

.

TNFSF13 (O)

Tumor necrosis factor superfamily member 13

IgA nephropathy

9 × 10⁻¹¹

22197929

x

.