Extended Data Fig. 2: Characterization of mutational signatures and driver events in priMMRD glioma. | Nature Genetics

Extended Data Fig. 2: Characterization of mutational signatures and driver events in priMMRD glioma.

From: Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma

Extended Data Fig. 2

a, Average Cosmic v3.2 SBS signature contributions across priMMRD subgroups. Signatures are colored and grouped by etiology. b, Total microsatellite InDel burden across priMMRD-HGG subgroups. Colored diamonds indicate median value. Two-sided Wilcoxon rank-sum test with Benjamini–Hochberg correction. Colored diamonds represent the median value. c, Polymerase epsilon (POLE) deficiency-specific microsatellite instability signature scores across priMMRD subgroups21. Two-sided Wilcoxon rank-sum test with Benjamini–Hochberg correction. Colored diamonds represent the median value. d, Oncoprint of glioma driver mutations and copy number alterations according to priMMRD-HGG subgroups and previously published cohorts of pediatric and adult MMRP glioma22,23. HGG, high-grade glioma; LGG, low-grade glioma; codel, 1p/19q co-deleted.

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