Fig. 2: Three-dimensional structure, from cryo-electron microscopy (PDB 6QW6), of the U4/U6 duplex and its interactions with neighboring splicing factors. | Nature Genetics

Fig. 2: Three-dimensional structure, from cryo-electron microscopy (PDB 6QW6), of the U4/U6 duplex and its interactions with neighboring splicing factors.

From: De novo and inherited dominant variants in U4 and U6 snRNA genes cause retinitis pigmentosa

Fig. 2

a, Naked U4/U6 pairing, showing the proximity of the causative variants identified (red and green). b, Same as in a with interacting PRPF proteins. c, Direct interactions of nucleotides of the U4/U6 duplex with PRPF31, via hydrogen bonds. d, Same as c but for PRPF3.

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