Extended Data Fig. 7: Shared and distinct heritable components between COPD and other traits. | Nature Genetics

Extended Data Fig. 7: Shared and distinct heritable components between COPD and other traits.

From: Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction

Extended Data Fig. 7

a–k, Comparison of effect sizes of variants from GWAS for COPD vs. four other traits (columns) across all available ancestry groups (rows) in models fitted with two lines. Effect sizes of variants on COPD are on the x-axis, and effect sizes of variants on the other traits are on the y-axis. Each point represents a variant significantly associated (P < 5 × 10−8) with at least one of the corresponding pair of traits. In a shared variants analysis, variants predominantly (with posterior probability >99%) associated with COPD are colored blue, and variants predominantly associated with the other trait are colored red. Gray variants were not confidently assigned to either trait (posterior probability < 99%). The colored shaded ellipse range indicates the 95% probability regions of the fitted bivariate effect size distributions with each class. Empty space means either the two traits do not have enough overlapped variants or GWAS results are not applicable for the corresponding ancestry group.

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