Extended Data Fig. 4: Multi-ancestry GWAS of FEV1. | Nature Genetics

Extended Data Fig. 4: Multi-ancestry GWAS of FEV1.

From: Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction

Extended Data Fig. 4

The largest published GWAS of FEV1 to date is depicted in the Manhattan plot in red (bottom, with its signals in orange dots). Integrating EAS results in a multi-ancestry meta-analysis identified new signals, depicted in the Manhattan plot in blue (top, with potentially novel loci in triangles). Unadjusted two-sided P values derived from METAL are on a −log10 scale. Novel loci with P < 10−10 are annotated with the nearest gene.

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