Extended Data Fig. 5: Xenium spatial transcriptomics-defined cell populations. | Nature Genetics

Extended Data Fig. 5: Xenium spatial transcriptomics-defined cell populations.

From: Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease

Extended Data Fig. 5: Xenium spatial transcriptomics-defined cell populations.

a, UMAP of 706,966 high-confidence cells profiled by high-resolution Xenium in situ sequencing. Only cells passing quality control and assigned confident cell-type annotations are shown; an additional 101,907 QC passed cells lacking high-confidence labels are not displayed. b–e, Feature plots of selected marker genes: (b) epithelial and related markers; (c) endothelial and fibroblast markers; (d) myeloid and lymphoid markers; (e) B cell markers and inflammatory genes (IL6, CSF3, CXCL10, IL4R, CCL2, ADAMTS4). f, Dot plot of marker genes for cell populations identified in the Xenium spatial transcriptomics analysis. Dot size indicates the proportion of expressing cells; color denotes scaled expression.

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