Fig. 2: STRING networks.
a, STRING network for 13 genes linked to the GWAS lead SNPs. Proteins involved in the ‘Termination of O-glycan biosynthesis’ pathway are colored light green, while proteins involved in ‘Glycosphingolipid biosynthesis—lacto and neolacto series’ are colored light blue. The two sets of proteins form a connected component, with ST6GAL1 and FUT3 acting as the main bridges. The edge width is indicative of the confidence score for each association, with thicker edges denoting higher confidence scores. Proteins with no interactions are colored light gray. The resulting network can be viewed, explored and customized at https://version-12-0.string-db.org/cgi/network?networkId=bnOf0kS7q9qc. b, STRING network expanded with 15 additional interactors using a selectivity parameter of 1.0. Four interactors were removed because the corresponding genes were located in genomic loci already covered (FUT5, FUT6, MUC22, MUC3A). Additional proteins that belong to the ‘Termination of O-glycan biosynthesis’ pathway are shown in dark green, and additional proteins that belong to the ‘Glycosphingolipid biosynthesis—lacto and neolacto series’ pathway are shown in dark blue. Additional connected proteins not belonging to either of the two pathways are shown in beige. The addition of the extra proteins leads to a heavily interconnected network; for this reason, we have selected a special coloring scheme to distinguish between the different edges in the network. Solid lines represent associations between the 13 original genes and dashed lines represent associations from the 11 additional genes. Green edges show associations between the genes involved in the ‘Termination of O-glycan biosynthesis’ pathway, blue edges show associations between the genes involved in the ‘Glycosphingolipid biosynthesis—lacto and neolacto series’ pathway, and gray lines represent other associations. This network can also be accessed at https://version-12-0.string-db.org/cgi/network?networkId=bTU3KIbwyQXZ. The data underlying these networks are provided as source data.
