Fig. 1: GWAS and replications of gut microbiota species relative abundance.
a, Overall design of the discovery GWAS in HUNT and the subsequent replications in four Swedish cohorts (all 13 SNP–species associations for replication) and in the FINRISK cohort (four SNP–species associations available for replication). b, Total SNP-based heritability, estimated as the ratio of genetic variance (Vg) to phenotypic variance (Vp), given as mean with 95% confidence intervals for the 546 evaluated species using genome-wide complex trait analysis (GCTA). c, Manhattan plot summarizing the SNP associations with the 546 gut microbiota species evaluated in the discovery GWAS. Results after replication are shown in Table 1 and Supplementary Table 7. The unadjusted P values are based on two-sided z-tests. Red line indicates genome-wide significance (P < 5.0 × 10−8). Gray dotted line indicates study-wide significance threshold adjusted for number of effective tests (P < 1.3 × 10−10). The identified genetic loci (index SNP ± 500 kb) are annotated with the species with study-wide significant associations. QC, quality control.
