Fig. 3: Follow-up analyses of some novel genetic signals with possible implications for associated diseases.

a,b, Bayesian colocalization analyses demonstrating colocalized genetic signals for C. cateniformis and hemorrhoidal disease, with a posterior probability of a single shared causal variant of 99.8%. c,d, Bayesian colocalization analyses demonstrating colocalized genetic signals for C. cateniformis and MUC12 expression in rectum, with a posterior probability of a single shared causal variant of 99.96%. e,f, MUC12 expression in human sigmoid colon. e, MUC12 mRNA is indicated in red, MUC2 protein as a marker of Goblet cells in green, EpCAM (epithelial cell adhesion molecule) protein in yellow as a marker of colonocytes and nuclei in white. f, MUC12 mRNA is indicated in red, MUC12 protein in green, EpCAM protein in yellow as a marker of colonocytes and nuclei in white. The experiment was repeated three times using samples from four different individuals. g,h, Bayesian colocalization analyses providing evidence for colocalization of the genetic signals for the relative abundance of Clostridium sp900540255 and high cholesterol, with a posterior probability of a single shared causal variant of 80.3%.