Single-nucleus DNA sequencing analyses elucidated the heterogeneous evolution of the genomes of pancreatic cancer cells. The key features uncovered highlighted mechanisms of resistance to therapy that might support ongoing precision medicine efforts.
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This is a summary of: Zhang, H. et al. Genomic evolution of pancreatic cancer at single-cell resolution. Nat. Genet. https://doi.org/10.1038/s41588-025-02468-9 (2026).
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Single-nucleus DNA sequencing delves into the varied genomic evolution of pancreatic cancer. Nat Genet 58, 247–248 (2026). https://doi.org/10.1038/s41588-026-02514-0
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DOI: https://doi.org/10.1038/s41588-026-02514-0
