Extended Data Table 1 Rare single variants in GCEP-curated genes achieving significance

From: Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis

  1. Listed are variants that reached significance in the GCEP-targeted analysis (P < 3.20 × 10−5). Test statistics are shown for the discovery phase (ncases = 13,138; ncontrols = 69,775), replication phase (ncases = 4,781; ncontrols = 130,928), and the combined meta-analysis (Stouffer’s Z-score method, weighted by effective sample size). Association statistics were estimated using Firth’s logistic regression with profile penalized likelihood confidence intervals. P-values are two-tailed and presented uncorrected for multiple testing.
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