Extended Data Table 2 Genes achieving significance among GCEP-curated genes in URV burden analyses

From: Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis

  1. Listed are genes that reached significance in a targeted analysis among GCEP-curated genes in the URV burden analyses (P < 1.0 × 10−3). Test statistics are shown for the discovery phase (ncases = 13,138; ncontrols = 69,775), replication phase (ncases = 4,781; ncontrols = 130,928), and the combined meta-analysis (Stouffer’s Z-score method, weighted by effective sample size). Carrier frequencies, odds ratios (OR), and confidence intervals (CI) estimated using Firth’s logistic regression with profile penalized likelihood confidence intervals are presented for the most significant of the four variant filtering strategies. P-values are two-tailed, uncorrected for multiple testing, and estimated using the ACAT omnibus test combining the four variant filtering strategies.
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