Extended Data Fig. 10: HS GAGs regulate the Ang/Tie signaling pathway.
From: Sulfated glycans engage the Ang–Tie pathway to regulate vascular development
HS GAGs utilize two distinct binding modes to promote pathway activation. a, Endothelial cell-associated HS GAGs recruit agonistic ligands Ang1 and Ang4 to form HS-Ang-Tie2 complexes and elicit downstream signaling. b, HS GAGs also bind to the orphan receptor Tie1 to promote the Tie1-Tie2 interaction, which maintains Tie2 protein levels and prevents protein turnover at the cell surface to sustain downstream signaling.
