Extended Data Fig. 2: Specificity of lead VH domain binders.
From: Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
Bio-layer interferometry (BLI) binding traces of VH domains at 150 nM to RBD and two decoy antigens expressed as biotinylated Fc-fusions: programmed cell death protein 1 (PD-1), and platelet glycoprotein 4 (CD36). Respective VH show successful binding to RBD, but not to either of the decoy antigens.
