Extended Data Fig. 3: Computational design, experimental screening and enrichment analysis of the 4E1H design series.
From: Bottom-up de novo design of functional proteins with complex structural features
a, TopoBuilder assembly of the 4E1H topology. b, Detailed view on all positions experimentally sampled (green). c, Enrichment analysis of dual selection pressures, binding to 101F antibody and resistance to protease digestion. n = 92,779 unique sequences were analyzed that were found under both selection conditions. d, Residue preferences for indicated position in positively enriched versus negatively enriched sequences. See Extended Data Fig. 2 caption for further details.
