Extended Data Fig. 5: Electron density maps of ribosome-bound erythromycin and telithromycin.
From: Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance
a, c, Chemical structures of NPET-binding macrolide antibiotics erythromycin (a, ERY) and telithromycin (c, TEL). b, d, High-resolution 2Fo-Fc electron density maps (blue mesh) of ERY (b, green) and TEL (d, magenta) in complex with the T. thermophilus 70S ribosome viewed from two different perspectives. The refined models of ERY or TEL are displayed in their respective electron densities contoured at 1.0σ. Nitrogen atoms are colored blue; oxygens are red. Key chemical moieties of each drug are labeled.
