Extended Data Fig. 7: Alignment of the structures of A2058-methylated 70S ribosome with the ribosome-bound clindamycin or quinupristin.
From: Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance
Superposition of the current structure of A2058-methylated 70S ribosome with the structure of ribosome-bound lincosamide antibiotic clindamycin (yellow, PDB entry 4V7V24) (a, b) or streptogramin type B antibiotic quinupristin (teal, PDB entry 4U2646) (c, d). Nucleotides of the Erm-modified and unmodified ribosomes are shown in blue and light blue, respectively. Methylated A2058 residue is shown in blue with the methyl groups highlighted in orange. All structures were aligned based on domain V of the 23S rRNA.
