Extended Data Fig. 2: A divergent hub controlling allosteric coupling in Cdk2.
From: Allostery governs Cdk2 activation and differential recognition of CDK inhibitors
a) KM values for phosphorylation of a short peptide substrate (left) and RB (right), measured for WT Cdk2, Cdk2cdk4hub and Cdk4. Values are mean ± S.E.M; n = 4 independent experiments. b) DEER data for the Cdk2cdk4hub mutant bound to cyclinA with and without addition of saturating peptide substrate and AMPPNP.
