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VIROLOGY

Anti-HIV agents inspired by antibodies

Nature Chemical Biology volume 16, pages 483–484 (2020)Cite this article

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Emergence of drug resistance limits the efficacy of HIV drugs, which currently requires life-long administration. In vitro high-throughput screening for competition with a broadly neutralizing antibody of HIV identified a small molecule that extends the strategies for targeting HIV.

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Fig. 1: The functional domains in the HIV-1 Env, the paradigm of HIV entry and the inhibition mechanism of dequalinium and its analogs on HIV infection.

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Authors and Affiliations

  1. Key Laboratory of Medical Molecular Virology (MOE/MOH/CAM), School of Basic Medical Sciences, Fudan University, Xuhui District, Shanghai, China

    Shan Su & Shibo Jiang

  2. Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA

    Shibo Jiang

Authors
  1. Shan Su
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  2. Shibo Jiang
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Correspondence to Shibo Jiang.

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The authors declare no competing interests.

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Su, S., Jiang, S. Anti-HIV agents inspired by antibodies. Nat Chem Biol 16, 483–484 (2020). https://doi.org/10.1038/s41589-020-0521-1

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