Extended Data Fig. 1: TH1760 potently inhibited the 6-thio-dGTPase activity of NUDT15. | Nature Chemical Biology

Extended Data Fig. 1: TH1760 potently inhibited the 6-thio-dGTPase activity of NUDT15.

From: Development of a chemical probe against NUDT15

Extended Data Fig. 1

TH1760 had over 200-fold potency improvement as compared to TH884, shown using PPiLight inorganic pyrophosphate assay (Lonza, #LT07–610). Individual data of n = 2 independent experiments performed in duplicates shown with estimated IC50 values.

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