Extended Data Fig. 2: TH1760 demonstrated impressive selectivity. | Nature Chemical Biology

Extended Data Fig. 2: TH1760 demonstrated impressive selectivity.

From: Development of a chemical probe against NUDT15

Extended Data Fig. 2: TH1760 demonstrated impressive selectivity.

a, TH1760 and TH7285 selectivity at 12 µM against a curated library of 44 kinases, tested using DSF with staurosporine as the positive control compound. Mean change in protein Tm (ΔTm) of one experiment performed in triplicates shown. b, TH1760 selectivity at 10 µM against the SafetyScreen44TM panel from Eurofins Cerep Panlabs. Mean % inhibition of an experiment performed in duplicates shown.

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