Extended Data Fig. 4: Bile acid concentrations in feces of human patients pre-SG or post-SG.
From: Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
Feces were collected from patients pre-op or ~5 weeks post-op and bile acids were quantified using UPLC-MS (n = 17 patients, median 36 days after surgery, data not marked with asterisk(s) are not significant). All bile acids with measurable concentrations above the limit of detection are shown. TCDCA, tauro-chenodeoxycholic acid, p = 0.97; TDCA, tauro-deoxycholic acid, p = 0.93; CA, cholic acid, **p = 1.00×10-3; CDCA, chenodeoxycholic acid, p = 0.52; DCA, deoxycholic acid, p = 0.13; LCA, lithocholic acid, *p = 0.01; isoLCA, iso-lithocholic acid, *p = 0.03; UDCA, ursodeoxycholic acid, *p = 0.02; 3-oxo-CDCA, 3-oxo-chenodeoxycholic acid, p = 0.92; 7-oxo-CDCA, 7-oxo-chenodeoxycholic acid, p = 0.47, 3-oxo-LCA, 3-oxo-lithocholic acid, p = 0.56, two-tailed paired t-test. All data are presented as mean ± SEM.
