Extended Data Fig. 7: Bile acid concentrations in cecal contents of mice gavaged with one dose of CA7S.
From: Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
Fasted DIO mice were gavaged with CA7S or PBS and cecal contents were collected from mice 5 hours post-gavage. Bile acids were quantified using UPLC-MS (n = 8 in each group, data not marked with asterisk(s) are not significant). All bile acids with measurable concentrations above the limit of detection are shown. Total BAs without CA7S, p = 0.35; Total bile acids (BAs), p = 0.06; Tα/βMCA, tauro-alpha- and tauro-beta-muricholic acid, p = 0.58; TγMCA, tauro-gamma-muricholic acid, p = 0.32; TCA, tauro-cholic acid, p = 0.13; TUDCA, tauro-ursodeoxycholic acid, p = 0.12; TCDCA, tauro-chenodeoxycholic acid, p = 0.13; CDCA, chenodeoxycholic acid, p = 0.33; αβMCA, alpha-muricholic acid and beta-muricholic acid, p = 0.96; CA, cholic acid, p = 0.38; TDCA, tauro-deoxycholic acid, p = 0.27; UDCA, ursodeoxycholic acid, p = 0.87; 3-oxo-CA, 3-oxo-cholic acid, p = 0.93; LCA, lithocholic acid, p = 0.86; DCA, deoxycholic acid, p = 0.76, two-tailed Welch’s t-test. All data are presented as mean ± SEM.
