Extended Data Fig. 3: Bile acid concentrations in cecal contents of mice post-sham or post-SG.
From: Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
Six weeks following surgery, cecal contents were collected from sham or SG mice after an overnight fast. Bile acids were quantified using UPLC-MS (sham, n = 12, SG, n = 15, data not marked with asterisk(s) are not significant). All bile acids with measurable concentrations above the limit of detection are shown. Tα/βMCA, tauro-alpha- and tauro-beta-muricholic acid, p = 0.53; TCA, tauro-cholic acid, p = 0.32; TγMCA, tauro-gamma-muricholic acid, p = 0.36; TωMCA, tauro-omega-muricholic acid, p = 0.68; TUDCA, tauro-ursodeoxycholic acid, p = 0.67; 7-oxo-TCDCA, 7-oxo-tauro-chenodeoxycholic acid p = 0.34; αMCA, alpha-muricholic acid, p = 0.87; βMCA, beta-muricholic acid, p = 0.59; CA, cholic acid, p = 0.28; UDCA, ursodeoxycholic acid, p = 0.85; DCA, deoxycholic acid, p = 0.48; LCA, lithocholic acid, *p = 0.02; isoLCA, isolithocholic acid *p = 0.02; 3-oxo-CA, 3-oxo-cholic acid, p = 0.08; 3-oxo-LCA, 3-oxo-lithocholic acid, p = 0.79; CDCA, chenodeoxycholic acid, *p = 0.03, two-tailed Welch’s t-test. All data are presented as mean ± SEM.
