Extended Data Fig. 1: Functional characterization of the C-terminal tail of SMO in HH signaling.
From: Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
The domain structure of SMO is shown above. HH signaling in Smo−/− mouse embryonic fibroblasts (MEFs) transfected with pcDNA3.1 and SMO variants was measured via luciferase activity. Error bars denote s.d. (n = 3 biologically independent experiments).
